Potential Mediator of Inflammation

Follistatin-Like 1: A Potential Mediator of Inflammation in Obesity

Obesity is associated with a state of chronic low-grade inflammation, which contributes to insulin resistance and type 2 diabetes. However, the molecular mechanisms that link obesity to inflammation are not fully understood. Follistatin-like 1 (FSTL1) is a novel proinflammatory cytokine that is expressed in adipose tissue and secreted by preadipocytes/adipocytes. We aimed to test whether FSTL1 ...

Complement as a Mediator of Inflammation

Interaction in free solution of highly purified preparations of human C'1 esterase, C'4, C'2, and C'3, in the presence of Mg(2+), resulted in rapid generation of an activity indistinguishable by biological criteria from anaphylatoxin. The formation of anaphylatoxin was associated with immunoelectrophoretic conversion of C'3 to anodically faster migrating proteins and was unaffected by the prese...

miR-200c Regulates IL8 Expression by Targeting IKBKB: A Potential Mediator of Inflammation in Leiomyoma Pathogenesis

We have previously reported that leiomyoma expressed lower levels of miR-200c and elevated IL8 as compared to paired myometrium. Here we addressed the regulatory functions of miR-200c on the expression of inflammatory mediators and cellular viability using leiomyomas and paired myometrium and their isolated primary smooth muscle cells. Our results indicated that gain-of function or knockdown of...

Inflammation Mediator of Cardiac Fibrosis Associated with Arachidonic Acid Metabolism as a Potential

Chronic Inflammation in Sickle Cell Disease: Potential Role of Platelets and the Inflammatory Mediator CD40L

Chronic inflammation is a poorly understood, but problematic, manisfestation of sickle cell disease (SCD). The potent inflammatory mediator CD40L increases leukocyte proliferation, endothelial adhesiveness and procoagulant activity once it is exposed and released from encrypted sites following platelet activation. Since elevated leukocyte counts, adhesion and coagulation are associated with mor...